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In principle, dosage and mode of administration is based on the type of severity of the circulatory disorder and on how the individual patient tolerates the drug. Dosage is generally based on the following guidelines and is determined by the physician in accordance with individual requirements.
Usual dose: 1 tab 2 or 3 times daily. The tablets are to be swallowed whole during or shortly after a meal with sufficient amounts of liquid (approximately 1/2 glass).
In patients with marked impairment of renal function (creatinine clearance < 10 mL/ min), it may be necessary to reduce the dose to 2 or 1 tablet daily.
The precise reduction implemented will vary depending o n how the patient tolerates the drug.
A dose reduction, guided by individual tolerance is necessary in patients with severely impaired liver function.
Treatment must be started with low doses in hypotensive patients or patients whose circulation is unstable as well as in patients who would be at particular risk from a reduction in blood pressure (e.g. patients with severe coronary heart disease or relevant stenoses of blood vessels supplying the brain): in such cases, the dose must be increased only gradually.
